BDBM50447094 CHEMBL1972466

SMILES CC(Nc1ccccc1)c1cc(C)cn2c1nc(cc2=O)N1CCOCC1

InChI Key InChIKey=CPRAGQJXBLMUEL-UHFFFAOYSA-N

Data  19 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50447094   

LigandPNGBDBM50447094(CHEMBL1972466)
Affinity DataIC50:  30nMAssay Description:Inhibition of N-terminal ploy-His-tagged human PI3Kbeta expressed in baculovirus-infected sf21 cells using PI(4,5)P2 as substrate after 15 mins by HT...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50447094(CHEMBL1972466)
Affinity DataIC50:  65nMAssay Description:Inhibition of PI3Kbeta (unknown origin) incubated for 60 mins in the presence of ATP by Kinase-Glo luminescence assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50447094(CHEMBL1972466)
Affinity DataIC50:  49nMAssay Description:Inhibition of human recombinant PI3Kbeta assessed as PIP3 production by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50447094(CHEMBL1972466)
Affinity DataIC50:  5.80E+3nMAssay Description:Inhibition of human recombinant PI3Kalpha assessed as PIP3 production by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50447094(CHEMBL1972466)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of PI3K p110alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50447094(CHEMBL1972466)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of PI3K p110beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50447094(CHEMBL1972466)
Affinity DataIC50:  140nMAssay Description:Inhibition of N-terminal His-tagged human p110delta expressed in Sf9 cells co-expressing p85alpha regulatory subunit using phosphatidylinositol subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50447094(CHEMBL1972466)
Affinity DataIC50:  4nMAssay Description:Inhibition of N-terminal His-tagged human p110beta expressed in Sf9 cells co-expressing p85alpha regulatory subunit using phosphatidylinositol substr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50447094(CHEMBL1972466)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of N-terminal His-tagged human p110alpha expressed in Sf9 cells co-expressing p85alpha regulatory subunit using phosphatidylinositol subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50447094(CHEMBL1972466)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of C-terminal ploy-His-tagged human PI3Kgamma expressed in baculovirus-infected sf9 cells using PI(4,5)P2 as substrate after 15 mins by HT...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50447094(CHEMBL1972466)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of N-terminal ploy-His-tagged human PI3Kalpha expressed in baculovirus-infected sf9 cells using PI(4,5)P2 as substrate after 15 mins by HT...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50447094(CHEMBL1972466)
Affinity DataIC50:  52nMAssay Description:Inhibition of PI3Kbeta (unknown origin) expressed in Escherichia coli-infected fall armyworm sf21 cells co-expressing p85 by kinase-glo luminescence ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50447094(CHEMBL1972466)
Affinity DataIC50:  851nMAssay Description:Inhibition of N-terminal ploy-His-tagged human PI3Kdelta expressed in baculovirus-infected sf9 cells using PI(4,5)P2 as substrate after 15 mins by HT...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50447094(CHEMBL1972466)
Affinity DataIC50:  10nMAssay Description:Inhibition of N-terminal ploy-His-tagged human PI3Kbeta expressed in baculovirus-infected sf21 cells using PI(4,5)P2 as substrate after 15 mins by HT...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50447094(CHEMBL1972466)
Affinity DataIC50:  63nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110beta/human recombinant full-length untagged p85alpha expressed in baculovirus ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50447094(CHEMBL1972466)
Affinity DataIC50:  7.60E+3nMAssay Description:Inhibition of human full length p110alpha/p85alpha using PIP2 as substrate after 30 mins in presence of ATP at 2xKm concentration by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50447094(CHEMBL1972466)
Affinity DataIC50:  500nMAssay Description:Inhibition of human p110delta catalytic subunit/p85alpha using PIP2 as substrate after 30 mins in presence of ATP at 2xKm concentration by TR-FRET as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50447094(CHEMBL1972466)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human full length p110gamma using PIP2 as substrate after 30 mins in presence of ATP at 2xKm concentration by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50447094(CHEMBL1972466)
Affinity DataIC50:  22nMAssay Description:Inhibition of PI3Kbeta in human MAD-MB-468 cells assessed as inhibition of Ser473 Akt phosphorylation by cellular potency assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed