BDBM50447625 CHEMBL3112712

SMILES COc1ncc(cc1NS(=O)(=O)c1ccc(F)cc1F)-c1cc2c(C)nc(N)cc2n([C@H]2CC[C@H](O)CC2)c1=O

InChI Key InChIKey=KSXIBIZFJUHIMB-IYARVYRRSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50447625   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pkucare Pharmaceutical R & D Center

Curated by ChEMBL
LigandPNGBDBM50447625(CHEMBL3112712)
Affinity DataIC50:  9.90nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2/PS as substrate compound preincubated for 15 mins by luciferase-based luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pkucare Pharmaceutical R & D Center

Curated by ChEMBL
LigandPNGBDBM50447625(CHEMBL3112712)
Affinity DataIC50:  29nMAssay Description:Inhibition of mTOR (unknown origin) after 40 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed