BDBM50447783 CHEMBL3113773::US9242970, 196

SMILES COc1cccc(OC)c1C1CCC(=O)N1Cc1ccc(OC(F)(F)F)cc1

InChI Key InChIKey=JXOZVFVJLIGZMP-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50447783   

TargetOrexin receptor type 2(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM50447783(CHEMBL3113773 | US9242970, 196)
Affinity DataIC50:  158nMT: 2°CAssay Description:In Vitro Assay: Intracellular Calcium Measurements:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 re...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM50447783(CHEMBL3113773 | US9242970, 196)
Affinity DataIC50:  724nMT: 2°CAssay Description:In Vitro Assay: Intracellular Calcium Measurements:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 re...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM50447783(CHEMBL3113773 | US9242970, 196)
Affinity DataIC50:  158nMAssay Description:Antagonist activity at human orexin 2 receptor expressed in CHO cells assessed as inhibition of orexin-A-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM50447783(CHEMBL3113773 | US9242970, 196)
Affinity DataIC50:  158nMAssay Description:Antagonist activity at human orexin 1 receptor expressed in CHO cells assessed as inhibition of orexin-A-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM50447783(CHEMBL3113773 | US9242970, 196)
Affinity DataIC50:  724nMAssay Description:Antagonist activity at human orexin 1 receptor expressed in CHO cells assessed as inhibition of orexin-A-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM50447783(CHEMBL3113773 | US9242970, 196)
Affinity DataIC50:  724nMAssay Description:Antagonist activity at human orexin 2 receptor expressed in CHO cells assessed as inhibition of orexin-A-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed