BDBM504500 2-{5-[(3-ethoxy-5-fluoropyridin-2- yl)oxy]pyridin-3-yl}-N-[(3S,4S)-4- fluoropiperidin-3-yl]pyrimidine-5- carboxamide, formate salt::US11065249, Example 13::US20230405002, Example 13

SMILES CCOc1cc(F)cnc1Oc1cncc(c1)-c1ncc(cn1)C(=O)N[C@H]1CNCC[C@@H]1F

InChI Key InChIKey=XZBQFIHUGFHQGB-ROUUACIJSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 504500   

TargetDiacylglycerol O-acyltransferase 2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM504500(2-{5-[(3-ethoxy-5-fluoropyridin-2- yl)oxy]pyridin-...)
Affinity DataIC50:  57nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol O-acyltransferase 2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM504500(2-{5-[(3-ethoxy-5-fluoropyridin-2- yl)oxy]pyridin-...)
Affinity DataIC50:  57nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol O-acyltransferase 2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM504500(2-{5-[(3-ethoxy-5-fluoropyridin-2- yl)oxy]pyridin-...)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of DGAT2 in human hepatocytes using [14C]-glycerol as substrate preincubated for 15 mins followed by substrate addition and measured after...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed