BDBM50452393 CHEMBL4212760

SMILES CC(C)[C@@H]1N=C(c2ccccc2F)c2cc(Cl)ccc2NC1=S

InChI Key InChIKey=IIYOCBNZOLLZCM-INIZCTEOSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50452393   

TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Roche Pharma Research And Early Development

Curated by ChEMBL
LigandPNGBDBM50452393(CHEMBL4212760)
Affinity DataEC50:  80nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Roche Pharma Research And Early Development

Curated by ChEMBL
LigandPNGBDBM50452393(CHEMBL4212760)
Affinity DataEC50:  178nMAssay Description:Positive allosteric modulation of M1 receptor Y179A/W400A mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
Roche Pharma Research And Early Development

Curated by ChEMBL
LigandPNGBDBM50452393(CHEMBL4212760)
Affinity DataEC50:  1.30E+3nMAssay Description:Positive allosteric modulation of M5 receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Roche Pharma Research And Early Development

Curated by ChEMBL
LigandPNGBDBM50452393(CHEMBL4212760)
Affinity DataEC50:  218nMAssay Description:Positive allosteric modulation of rat M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed