BDBM50457446 CHEMBL4212692

SMILES CCCS(=O)(=O)Nc1ccc(F)c(c1F)-n1cc(-c2cncnc2)c2nc(ccc12)N(C)C1CCN(CC)CC1

InChI Key InChIKey=AEJACXAFHXBVHF-UHFFFAOYSA-N

Data  5 IC50  2 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50457446   

TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Albert Einstein College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50457446(CHEMBL4212692)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of CRAF (unknown origin) by Z'-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Albert Einstein College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50457446(CHEMBL4212692)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of BRAF V600E mutant in human A375 cells assessed as reduction in ERK phosphorylation after 2 hrs by ELISAMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Albert Einstein College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50457446(CHEMBL4212692)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of wild type BRAF (unknown origin) by Z'-LYTE assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Albert Einstein College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50457446(CHEMBL4212692)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of BRAF (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Albert Einstein College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50457446(CHEMBL4212692)
Affinity DataKd:  0.330nMAssay Description:Binding affinity to DNA-tagged BRAF (unknown origin) V600E mutant by KINOMEscan assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Albert Einstein College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50457446(CHEMBL4212692)
Affinity DataKd:  0.370nMAssay Description:Binding affinity to DNA-tagged BRAF (unknown origin) by KINOMEscan assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Albert Einstein College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50457446(CHEMBL4212692)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of BRAF V600E mutant (unknown origin) by Z'-LYTE assayMore data for this Ligand-Target Pair