BDBM50457986 CHEMBL4209777

SMILES O=C(Nc1ccccc1-c1nnn(n1)-c1ccccc1)C12CC3CC(CC(C3)C1)C2

InChI Key InChIKey=CNMKKLGKUOVNHL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50457986   

TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universit£T Bonn

Curated by ChEMBL
LigandPNGBDBM50457986(CHEMBL4209777)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of ABCB1 in human A2780adr cells assessed as reduction in calcein AM levels preincubated for 30 mins followed by calcein AM addition measu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universit£T Bonn

Curated by ChEMBL
LigandPNGBDBM50457986(CHEMBL4209777)
Affinity DataIC50:  1.06E+3nMAssay Description:Inhibition of C-terminal GFP-fused human ABCG2 expressed in MDCK2 cells preincubated for 30 mins followed by Hoechst 33342 addition and measured ever...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed