BDBM50459029 CHEMBL4218962::US10611730, Example 56

SMILES Clc1cccc(C#N)c1-c1ccc2[nH]c(=O)[nH]c2c1

InChI Key InChIKey=SAATUQRGWSHZJD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50459029   

TargetGlutamate receptor 1/Voltage-dependent calcium channel gamma-8 subunit(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50459029(CHEMBL4218962 | US10611730, Example 56)
Affinity DataIC50:  251nMAssay Description:Modulation of recombinant human GluA1 flop isoform/TARPgamma8 expressed in HEK293F cells assessed as blockade of glutamate-induced calcium flux by ca...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVoltage-dependent calcium channel gamma-8 subunit(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50459029(CHEMBL4218962 | US10611730, Example 56)
Affinity DataIC50:  631nMAssay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutamate receptor 1/Voltage-dependent calcium channel gamma-2 subunit(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50459029(CHEMBL4218962 | US10611730, Example 56)
Affinity DataIC50: <1.00E+4nMAssay Description:Modulation of recombinant human GluA1 flop isoform/TARPgamma2 expressed in HEK293F cells assessed as blockade of glutamate-induced calcium flux by ca...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed