BDBM50459054 CHEMBL4213248
SMILES NC(=N)NC(=O)c1nc(-c2cc3ccccc3o2)c(nc1N)N1CCCCCC1
InChI Key InChIKey=FSPGYSVEHLETQR-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 13 hits for monomerid = 50459054
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
University Of Wollongong
Curated by ChEMBL
University Of Wollongong
Curated by ChEMBL
Affinity DataKi: 183nMAssay Description:Inhibition of human kidney uPA using Z-Gly-Gly-Arg-AMC as substrate measured over 15 mins by fluorescence assayMore data for this Ligand-Target Pair
3D Structure (crystal)TargetUrokinase-type plasminogen activator(Mus musculus (Mouse))
University Of Wollongong
Curated by ChEMBL
University Of Wollongong
Curated by ChEMBL
Affinity DataKi: 1.80E+3nMAssay Description:Inhibition of mouse uPA using Z-Gly-Gly-Arg-AMC as substrate after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of trypsin (unknown origin) using chromogenic H-D-Ile-L-Pro-L-Arg-p-nitoraniline as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of factor 10a (unknown origin) using chromogenic H-D-Ile-L-Pro-L-Arg-p-nitoraniline as substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
University Of Wollongong
Curated by ChEMBL
University Of Wollongong
Curated by ChEMBL
Affinity DataIC50: <3.00E+3nMAssay Description:Inhibition of recombinant human Nav1.5alpha expressed in HEK293 cells incubated for 10 mins by voltage clamp methodMore data for this Ligand-Target Pair
TargetTissue-type plasminogen activator(Homo sapiens (Human))
University Of Wollongong
Curated by ChEMBL
University Of Wollongong
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of tPA (unknown origin) using chromogenic H-D-Ile-L-Pro-L-Arg-p-nitoraniline as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.13E+4nMAssay Description:Inhibition of human plasma kallikrein using chromogenic L-pyroGlu-L-Pro-L-Arg-p-nitroaniline as substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
University Of Wollongong
Curated by ChEMBL
University Of Wollongong
Curated by ChEMBL
Affinity DataIC50: 530nMAssay Description:Inhibition of human kidney uPA using chromogenic H-D-Ile-L-Pro-L-Arg-p-nitoraniline as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.10E+4nMAssay Description:Inhibition of factor 11a (unknown origin) using chromogenic L-pyroGlu-L-Pro-L-Arg-p-nitroaniline as substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University Of Wollongong
Curated by ChEMBL
University Of Wollongong
Curated by ChEMBL
Affinity DataIC50: <3.00E+3nMAssay Description:Inhibition of recombinant human ERG expressed in CHO cells incubated for 12 mins by whole cell voltage clamp methodMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of thrombin (unknown origin) using chromogenic H-D-Ile-L-Pro-L-Arg-p-nitoraniline as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of activated protein C (unknown origin) using chromogenic L-pyroGlu-L-Pro-L-Arg-p-nitroaniline as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of plasmin (unknown origin) using chromogenic H-D-Ile-L-Pro-L-Arg-p-nitoraniline as substrate by fluorescence assayMore data for this Ligand-Target Pair