BDBM50460714 CHEMBL4228176
SMILES CCN(CC)C1CCN(CC1)c1ccc(Nc2nccc(NC(=O)Nc3cccc(NC(=O)C=C)c3)n2)c(OC)c1
InChI Key InChIKey=MMIVMSNIAOAVSX-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50460714
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shanghai Haiyan Pharmaceutical Technology Co. Itd.
Curated by ChEMBL
Shanghai Haiyan Pharmaceutical Technology Co. Itd.
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human GST-tagged EGFR L858R/T790M mutant cytoplasmic domain (668 to 1210 residues) expressed in baculovirus expression syst...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shanghai Haiyan Pharmaceutical Technology Co. Itd.
Curated by ChEMBL
Shanghai Haiyan Pharmaceutical Technology Co. Itd.
Curated by ChEMBL
Affinity DataIC50: 55nMAssay Description:Inhibition of EGFR L858R/T790M mutant phosphorylation in human NCI-H1975 cells after 1 hr by ELISAMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shanghai Haiyan Pharmaceutical Technology Co. Itd.
Curated by ChEMBL
Shanghai Haiyan Pharmaceutical Technology Co. Itd.
Curated by ChEMBL
Affinity DataIC50: 36nMAssay Description:Inhibition of recombinant human GST-tagged wild-type EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus expression system using ...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shanghai Haiyan Pharmaceutical Technology Co. Itd.
Curated by ChEMBL
Shanghai Haiyan Pharmaceutical Technology Co. Itd.
Curated by ChEMBL
Affinity DataIC50: 1.01E+3nMAssay Description:Inhibition of wild-type EGFR phosphorylation in human A431 cells preincubated for 1 hr followed by EGF stimulation measured after 45 mins by ELISAMore data for this Ligand-Target Pair