BDBM50463507 CHEMBL4247751

SMILES Cc1nc2ccc(c(C)c2c(=O)[nH]1)-c1ccnc2ccccc12

InChI Key InChIKey=CNEUJSQUCXSRDD-UHFFFAOYSA-N

Data  1 IC50  8 Kd

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50463507   

TargetActivin receptor type-1(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50463507(CHEMBL4247751)
Affinity DataKd:  640nMAssay Description:Binding affinity to human ALK2 by KdELECT assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50463507(CHEMBL4247751)
Affinity DataKd:  330nMAssay Description:Binding affinity to partial length human RAF1 (I330 to T640 residues) expressed in bacterial expression system by KdELECT assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50463507(CHEMBL4247751)
Affinity DataKd:  41nMAssay Description:Binding affinity to human ALK1 by KdELECT assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50463507(CHEMBL4247751)
Affinity DataKd:  65nMAssay Description:Binding affinity to partial length human BRAF (S429 to E741 residues) expressed in mammalian expression system by KdELECT assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50463507(CHEMBL4247751)
Affinity DataKd:  2.70E+3nMAssay Description:Binding affinity to human ALK3 by KdELECT assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetActivin receptor type-1B(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50463507(CHEMBL4247751)
Affinity DataKd:  690nMAssay Description:Binding affinity to human ALK4 by KdELECT assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50463507(CHEMBL4247751)
Affinity DataKd:  1.00E+3nMAssay Description:Binding affinity to human ALK5 by KdELECT assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50463507(CHEMBL4247751)
Affinity DataIC50:  42nMAssay Description:Inhibition of recombinant GST-tagged human ALK2 catalytic domain (145 to 509 residues) expressed in Baculovirus expression system by FRET-based Lanth...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetBone morphogenetic protein receptor type-1B(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50463507(CHEMBL4247751)
Affinity DataKd:  39nMAssay Description:Binding affinity to human ALK6 by KdELECT assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed