BDBM50463840 CHEMBL4239361

SMILES NC(=O)c1cnc2[nH]ccc2c1NC12CC3CC(CC(C3)C1)C2

InChI Key InChIKey=XUWWTDITFKFAPU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50463840   

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50463840(CHEMBL4239361)
Affinity DataIC50:  120nMAssay Description:Inhibition of recombinant human N-terminal His-tagged JAK2 catalytic domain (826 to 1132 residues) expressed in baculovirus expression system using B...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50463840(CHEMBL4239361)
Affinity DataIC50:  110nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged JAK1 catalytic domain (850 to 1154 residues) expressed in baculovirus expression system using B...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50463840(CHEMBL4239361)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant human N-terminal His-tagged JAK3 catalytic domain (795 to 1124 residues) expressed in baculovirus expression system using B...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed