BDBM50464455 CHEMBL4294528::US11565996, Compound Colletochlorin B

SMILES [#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-c1c(-[#8])c(Cl)c(-[#6])c(-[#6]=O)c1-[#8]

InChI Key InChIKey=UEUMAXMCCDEOIJ-XYOKQWHBSA-N

Data  4 IC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50464455   

TargetAlternative oxidase, mitochondrial(Trypanosoma brucei brucei)
University Of Sussex

Curated by ChEMBL
LigandPNGBDBM50464455(CHEMBL4294528 | US11565996, Compound Colletochlori...)
Affinity DataIC50:  4nMAssay Description:Inhibition of recombinant His-tagged and SUMO-tagged Trypanosoma alternative oxidase expressed in Escherichia coli Rosetta2 using 1-ubiquinol as subs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetUbiquinol oxidase 1, mitochondrial(Voodoo lily)
Alternox Scientific

US Patent
LigandPNGBDBM50464455(CHEMBL4294528 | US11565996, Compound Colletochlori...)
Affinity DataIC50:  750nMAssay Description:Table 1 summarises the concentration of inhibitor required to reduce the respiration of purified recombinant AOX protein by 50%. Respiration was meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetUbiquinol oxidase 1, mitochondrial(Voodoo lily)
Alternox Scientific

US Patent
LigandPNGBDBM50464455(CHEMBL4294528 | US11565996, Compound Colletochlori...)
Affinity DataIC50:  515nMAssay Description:Table 1 summarises the concentration of inhibitor required to reduce the respiration of purified recombinant AOX protein by 50%. Respiration was meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetAlternative oxidase, mitochondrial(Trypanosoma brucei brucei)
University Of Sussex

Curated by ChEMBL
LigandPNGBDBM50464455(CHEMBL4294528 | US11565996, Compound Colletochlori...)
Affinity DataIC50:  3.98nMAssay Description:Inhibition of recombinant His-tagged and SUMO-tagged Trypanosoma alternative oxidase expressed in Escherichia coli Rosetta2 using 1-ubiquinol as subs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB