Reaction Details Report a problem with these data
Target
Ubiquinol oxidase 1, mitochondrial
Ligand
BDBM50464455
Substrate
n/a
Meas. Tech.
Inhibitory Effects on Recombinant AOX Protein
IC50
515±n/a nM
Citation
 Moore, AL; Albury, MS; Young, LE; Elliott, C Compounds for use as inhibitors of alternative oxidase or cytochrome bc1 complex US Patent  US11565996 Publication Date 1/31/2023 
Target
Name:
Ubiquinol oxidase 1, mitochondrial
Synonyms:
AOX1 | AOX1_SAUVE | Alternative oxidase 1
Type:
Protein
Mol. Mass.:
38937.07
Organism:
Voodoo lily
Description:
P22185
Residue:
349
Sequence:
MMSSRLVGTALCRQLSHVPVPQYLPALRPTADTASSLLHGCSAAAPAQRAGLWPPSWFSPPRHASTLSAPAQDGGKEKAAGTAGKVPPGEDGGAEKEAVVSYWAVPPSKVSKEDGSEWRWTCFRPWETYQADLSIDLHKHHVPTTILDKLALRTVKALRWPTDIFFQRRYACRAMMLETVAAVPGMVGGVLLHLKSLRRFEHSGGWIRALLEEAENERMHLMTFMEVAQPRWYERALVLAVQGVFFNAYFLGYLLSPKFAHRVVGYLEEEAIHSYTEFLKDIDSGAIQDCPAPAIALDYWRLPQGSTLRDVVTVVRADEAHHRDVNHFASDVHYQDLELKTTPAPLGYH
  
Inhibitor
Name:
BDBM50464455
Synonyms:
CHEMBL4294528 | US11565996, Compound Colletochlorin B
Type:
Small organic molecule
Emp. Form.:
C18H23ClO3
Mol. Mass.:
322.826
SMILES:
[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-c1c(-[#8])c(Cl)c(-[#6])c(-[#6]=O)c1-[#8]
Structure:
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