BDBM50465367 CHEMBL4293269

SMILES [H][C@@]12COC[C@@H](C)N1c1nc(nc(c1OC2)C(C)(C)S(C)(=O)=O)-c1c(NCC)cnc2[nH]ccc12

InChI Key InChIKey=PAEFRKXGUAROEW-KGLIPLIRSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50465367   

TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM50465367(CHEMBL4293269)
Affinity DataIC50:  10nMAssay Description:Inhibition of ATR in human HT29 cells assessed as reduction in Chk1 phosphorylation at Ser345 residues after 4 hrs by Alexa Fluor 488 staining based ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Homo sapiens (Human))
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM50465367(CHEMBL4293269)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant human full length ATR/ATRIP expressed in mammalian expression system using c-Myc-tagged p53 as substrate incubated for 15 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed