BDBM50465585 CHEMBL4279907::US10501466, Example B11
SMILES Clc1ccc(CC(=O)N[C@@H]2CCc3ccc(cc23)-c2cn3CCCc3n2)cc1Cl
InChI Key InChIKey=HLGZWOPKLXYBFI-HXUWFJFHSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50465585
Affinity DataKi: 2.5nMAssay Description:Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...More data for this Ligand-Target Pair
Affinity DataKi: 2.66nMAssay Description:A fluorescence polarization anisotropy (FPA) assay that measures the displacement of either a FITC-labeled MLL-derived peptide or a more potent 10mer...More data for this Ligand-Target Pair
Affinity DataKi: 2.70nMAssay Description:Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...More data for this Ligand-Target Pair
Affinity DataIC50: 9.27E+3nMAssay Description:Inhibition of human WDR5 (22 to 334 residues) assessed as reduction in WRAD-mediated human MLL1 ( 3745 to 3969 residues) H3K4 methylation using human...More data for this Ligand-Target Pair