BDBM50466210 CHEMBL4281048
SMILES COCCN[C@H]1CC[C@@H](CC1)Nc1cc(-c2csc(NCC3(CCOCC3)C#N)n2)c(Cl)cn1
InChI Key InChIKey=XSDZPPRQLIZLDG-IYARVYRRSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 14 hits for monomerid = 50466210
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 4.64E+3nMAssay Description:Inhibition of recombinant full length His/GST-tagged human CDK5/p25 expressed in baculovirus expression systemMore data for this Ligand-Target Pair
TargetCyclin-Y/Cyclin-dependent kinase 14(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 1.68E+3nMAssay Description:Inhibition of recombinant GST-tagged human full length CDK14/cyclin Y (2 to end residues)More data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 2.86E+3nMAssay Description:Inhibition of recombinant full length His-tagged human CDK2/CyclinA expressed in baculovirus expression systemMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 3/G1/S-specific cyclin-E1(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant GST-tagged human CDK3/cyclin E1More data for this Ligand-Target Pair
TargetCDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 1.72E+3nMAssay Description:Inhibition of recombinant full length His-tagged human CDK7/cyclin H/MNAT1 expressed in baculovirus expression systemMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant GST-tagged inactive state of human CDK11More data for this Ligand-Target Pair
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant full length His-tagged human CDK9/CyclinT1 expressed in baculovirus expression systemMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of CDK9/Cyclin K (unknown origin) using PDKtide as substrate incubated at 37 degreeC for 1 hr followed by incubation at room temperature f...More data for this Ligand-Target Pair
Affinity DataEC50: <100nMAssay Description:Inhibition of CDK9 in human MV4-11 cells assessed as decrease in RNA polymerase 2 phosphorylation at Ser 2 residues in CTD domain after 2 hrs by immu...More data for this Ligand-Target Pair
Affinity DataEC50: <100nMAssay Description:Inhibition of CDK9 in human HL60 cells assessed as decrease in RNA polymerase 2 phosphorylation at Ser 2 residues in CTD domain after 2 hrs by immuno...More data for this Ligand-Target Pair
Affinity DataEC50: <100nMAssay Description:Inhibition of CDK9 in human MEC1 cells assessed as decrease in RNA polymerase 2 phosphorylation at Ser 2 residues in CTD domain after 2 hrs by immuno...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 1.34E+3nMAssay Description:Inhibition of recombinant full length His-tagged human CDK1/CyclinB expressed in baculovirus expression systemMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant full length His-tagged human CDK8/CyclinC expressed in baculovirus expression systemMore data for this Ligand-Target Pair
TargetCyclin-Y/Cyclin-dependent kinase 16(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 292nMAssay Description:Inhibition of recombinant GST-tagged inactive state of human CDK16 (108 to end residues)/cyclin Y (2 to end residues)More data for this Ligand-Target Pair