BDBM50469353 CHEMBL4283353
SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(CN2CCCN(C)CC2)cc1
InChI Key InChIKey=HYUGTGGDEAGXJP-HRNNMHKYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 32 hits for monomerid = 50469353
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
Unc Eshelman School Of Pharmacy
Curated by ChEMBL
Unc Eshelman School Of Pharmacy
Curated by ChEMBL
Affinity DataKi: 0.430nMAssay Description:Inhibition of MERTK (unknown origin) using 5'-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by MCE assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Unc Eshelman School Of Pharmacy
Curated by ChEMBL
Unc Eshelman School Of Pharmacy
Curated by ChEMBL
Affinity DataKi: 3.90nMAssay Description:Inhibition of TYRO3 (unknown origin) using 5'-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by MCE assayMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Unc Eshelman School Of Pharmacy
Curated by ChEMBL
Unc Eshelman School Of Pharmacy
Curated by ChEMBL
Affinity DataKi: 16nMAssay Description:Inhibition of FLT3 (unknown origin) using 5'-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by MCE assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Unc Eshelman School Of Pharmacy
Curated by ChEMBL
Unc Eshelman School Of Pharmacy
Curated by ChEMBL
Affinity DataKi: 40nMAssay Description:Inhibition of AXL (unknown origin) using 5'-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by MCE assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Unc Eshelman School Of Pharmacy
Curated by ChEMBL
Unc Eshelman School Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 3.10nMAssay Description:Inhibition of N-terminal GST-tagged human TYRO3 cytoplasmic domain (453 to 890 end residues) expressed in baculovirus expression system using fluorec...More data for this Ligand-Target Pair
TargetSTE20-like serine/threonine-protein kinase(Homo sapiens (Human))
Unc Eshelman School Of Pharmacy
Curated by ChEMBL
Unc Eshelman School Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 47nMAssay Description:Inhibition of N-terminal GST-tagged full length human SLK (1 to 1152 end residues) expressed in baculovirus expression system using fluorecence-label...More data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Unc Eshelman School Of Pharmacy
Curated by ChEMBL
Unc Eshelman School Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: >100nMAssay Description:Inhibition of N-terminal GST-tagged human KIT cytoplasmic domain (544 to 976 end residues) expressed in baculovirus expression system using fluorecen...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
Unc Eshelman School Of Pharmacy
Curated by ChEMBL
Unc Eshelman School Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of MERTK in human 697 cells assessed as reduction in phosphorylated MERTK level preincubated for 1 hr followed by pervanadate phopshatase ...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Unc Eshelman School Of Pharmacy
Curated by ChEMBL
Unc Eshelman School Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 39nMAssay Description:Inhibition of FLT3 (unknown origin) using 5'-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by MCE assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Unc Eshelman School Of Pharmacy
Curated by ChEMBL
Unc Eshelman School Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 9.10nMAssay Description:Inhibition of TYRO3 (unknown origin) using 5'-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by MCE assayMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Unc Eshelman School Of Pharmacy
Curated by ChEMBL
Unc Eshelman School Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 2.5nMAssay Description:Inhibition of N-terminal GST-tagged human FLT3 cytoplasmic domain (564 to 993 end residues) expressed in baculovirus expression system using fluorece...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
Unc Eshelman School Of Pharmacy
Curated by ChEMBL
Unc Eshelman School Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Inhibition of N-terminal GST-tagged human MERTK cytoplasmic domain (528 to 999 end residues) expressed in baculovirus expression system using fluorec...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
Unc Eshelman School Of Pharmacy
Curated by ChEMBL
Unc Eshelman School Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 2.40nMAssay Description:Inhibition of MERTK (unknown origin) using 5'-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by MCE assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Unc Eshelman School Of Pharmacy
Curated by ChEMBL
Unc Eshelman School Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 80nMAssay Description:Inhibition of AXL (unknown origin) using 5'-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by MCE assayMore data for this Ligand-Target Pair
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Unc Eshelman School Of Pharmacy
Curated by ChEMBL
Unc Eshelman School Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 8.40nMAssay Description:Inhibition of N-terminal GST-tagged human TRKC cytoplasmic domain (456 to 825 end residues) expressed in baculovirus expression system using fluorece...More data for this Ligand-Target Pair
TargetNUAK family SNF1-like kinase 1(Homo sapiens (Human))
Unc Eshelman School Of Pharmacy
Curated by ChEMBL
Unc Eshelman School Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: >100nMAssay Description:Inhibition of N-terminal GST-tagged full length human NuaK1 (1 to 661 end residues) expressed in baculovirus expression system using fluorecence-labe...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Unc Eshelman School Of Pharmacy
Curated by ChEMBL
Unc Eshelman School Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:Inhibition of FLT3 in human SEM cells assessed as reduction in phosphorylated FLT3 level preincubated for 1 hr followed by pervanadate phopshatase in...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Unc Eshelman School Of Pharmacy
Curated by ChEMBL
Unc Eshelman School Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of N-terminal GST-tagged AXL (464 to 885 residues) (unknown origin) cytoplasmic domain expressed in Sf21 cellsMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
Unc Eshelman School Of Pharmacy
Curated by ChEMBL
Unc Eshelman School Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Inhibition of N-terminal GST-tagged MERTK (528 to 999 residues) (unknown origin) cytoplasmic domain expressed in Sf21 cellsMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Unc Eshelman School Of Pharmacy
Curated by ChEMBL
Unc Eshelman School Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 2.5nMAssay Description:Inhibition of N-terminal GST-tagged FLT3 (564 to 993 residues) (unknown origin) cytoplasmic domain expressed in Sf21 cellsMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Unc Eshelman School Of Pharmacy
Curated by ChEMBL
Unc Eshelman School Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 3.10nMAssay Description:Inhibition of N-terminal GST-tagged TYRO3 (453 to 890 residues) (unknown origin) cytoplasmic domain expressed in Sf21 cellsMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
University Of North Carolina At Chapel Hill
Curated by ChEMBL
University Of North Carolina At Chapel Hill
Curated by ChEMBL
Affinity DataIC50: 3.60nMAssay Description:Inhibition of N-terminal GST-tagged TRKA (436 to 790 residues) (unknown origin) cytoplasmic domain expressed in Sf21 cellsMore data for this Ligand-Target Pair
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Unc Eshelman School Of Pharmacy
Curated by ChEMBL
Unc Eshelman School Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 8.40nMAssay Description:Inhibition of N-terminal GST-tagged TRKC (456 to 825 residues) (unknown origin) cytoplasmic domain expressed in Sf21 cellsMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
University Of North Carolina At Chapel Hill
Curated by ChEMBL
University Of North Carolina At Chapel Hill
Curated by ChEMBL
Affinity DataIC50: 2.70nMAssay Description:Inhibition of N-terminal GST-tagged HGK (1 to 328 residues) (unknown origin) cytoplasmic domain expressed in Sf21 cellsMore data for this Ligand-Target Pair
TargetTRAF2 and NCK-interacting protein kinase(Homo sapiens (Human))
University Of North Carolina At Chapel Hill
Curated by ChEMBL
University Of North Carolina At Chapel Hill
Curated by ChEMBL
Affinity DataIC50: 5.80nMAssay Description:Inhibition of N-terminal GST-tagged TNIK (1 to 314 residues) (unknown origin) cytoplasmic domain expressed in Sf21 cellsMore data for this Ligand-Target Pair
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
University Of North Carolina At Chapel Hill
Curated by ChEMBL
University Of North Carolina At Chapel Hill
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of N-terminal GST-tagged TRKB (456 to 822 residues) (unknown origin) cytoplasmic domain expressed in Sf21 cellsMore data for this Ligand-Target Pair
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
University Of North Carolina At Chapel Hill
Curated by ChEMBL
University Of North Carolina At Chapel Hill
Curated by ChEMBL
Affinity DataIC50: 2.30nMAssay Description:Inhibition of N-terminal GST-tagged MELK (1 to 493 residues) (unknown origin) expressed in Escherichia coliMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))
Unc Eshelman School Of Pharmacy
Curated by ChEMBL
Unc Eshelman School Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: >100nMAssay Description:Inhibition of N-terminal GST-tagged full length human QIK (1 to 926 end residues) expressed in baculovirus expression system using fluorecence-labele...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Unc Eshelman School Of Pharmacy
Curated by ChEMBL
Unc Eshelman School Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of N-terminal GST-tagged human AXL cytoplasmic domain (464 to 885 end residues) expressed in baculovirus expression system using fluorecen...More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
University Of North Carolina At Chapel Hill
Curated by ChEMBL
University Of North Carolina At Chapel Hill
Curated by ChEMBL
Affinity DataIC50: >100nMAssay Description:Inhibition of PDGFRalpha (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Unc Eshelman School Of Pharmacy
Curated by ChEMBL
Unc Eshelman School Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 859nMAssay Description:Inhibition of AXL in human A549 cells assessed as reduction in phosphorylated AXL level preincubated for 1 hr followed by pervanadate phopshatase inh...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
University Of North Carolina At Chapel Hill
Curated by ChEMBL
University Of North Carolina At Chapel Hill
Curated by ChEMBL
Affinity DataIC50: 3.60nMAssay Description:Inhibition of N-terminal GST-tagged human TRKA cytoplasmic domain (436 to 790 end residues) expressed in baculovirus expression system using fluorece...More data for this Ligand-Target Pair