BDBM50471096 CHEMBL414613::RS-14491

SMILES Clc1cccc(c1)-c1nn(Cc2ccncc2)c(=O)c2cccnc12

InChI Key InChIKey=COLQUUDNEIJASV-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50471096   

TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50471096(CHEMBL414613 | RS-14491)
Affinity DataIC50:  5.10E+3nMAssay Description:Inhibitory activity against cGMP inhibited Phosphodiesterase 3, isolated from guinea pig ventricular tissueMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50471096(CHEMBL414613 | RS-14491)
Affinity DataIC50:  4.80nMAssay Description:Affinity for the high affinity rolipram binding site of phosphodiesterase (PDE IV) by [3H]rolipram displacement.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Dipartimento Di Scienze Farmaceutiche, Firenze, Italy.

Curated by ChEMBL
LigandPNGBDBM50471096(CHEMBL414613 | RS-14491)
Affinity DataIC50:  56nMAssay Description:Inhibition of guinea pig ventricular Phosphodiesterase 4More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50471096(CHEMBL414613 | RS-14491)
Affinity DataIC50:  4.80nMAssay Description:Displacement of [3H]rolipram from rat brain membranesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50471096(CHEMBL414613 | RS-14491)
Affinity DataIC50:  5.10E+3nMAssay Description:Inhibition of guinea pig ventricular Phosphodiesterase 3More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Dipartimento Di Scienze Farmaceutiche, Firenze, Italy.

Curated by ChEMBL
LigandPNGBDBM50471096(CHEMBL414613 | RS-14491)
Affinity DataIC50:  56nMAssay Description:Inhibitory activity against phosphodiesterase 4 isolated from guinea pig ventricular tissueMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed