BDBM50479788 CHEMBL486750

SMILES Cc1cc(ccc1[C@H]1CCCN1C(=O)c1cc(Cl)c(O)cc1O)C(=O)N1CC(F)(F)C1

InChI Key InChIKey=QUODKSAJAYXMND-UHFFFAOYSA-N

Data  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50479788   

TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50479788(CHEMBL486750)
Affinity DataIC50: 20nMAssay Description:Inhibition of Hsp90 in human H1299 cells after 24 hrs by Akt luminex assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50479788(CHEMBL486750)
Affinity DataIC50: 7.60nMAssay Description:Inhibition of Hsp90 in human MDA-MB-231 cells assessed as her2 degradationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50479788(CHEMBL486750)
Affinity DataIC50: 34nMAssay Description:Inhibition of Hsp90 in human A2058 cells assessed as Akt degradationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50479788(CHEMBL486750)
Affinity DataIC50: 19nMAssay Description:Inhibition of Hsp90 in human MDA-MB-231 cells assessed as Akt degradationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50479788(CHEMBL486750)
Affinity DataEC50:  18nMAssay Description:Inhibition of Hsp90 in human A2058 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed