BDBM50484296 CHEMBL1837043

SMILES FC(F)(F)c1ccc(cn1)S(=O)(=O)N1C2CC(CC1c1cn[nH]c1C2)c1ccccc1

InChI Key InChIKey=DDQNBVZKZXCOQE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50484296   

TargetPresenilin-1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50484296(CHEMBL1837043)
Affinity DataIC50:  7.47E+3nMAssay Description:Inhibition of gamma-secretase-mediated notch cleavage in human SNC-204B8 cells after 16 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50484296(CHEMBL1837043)
Affinity DataIC50:  16nMAssay Description:Inhibition of gamma-secretase-mediated cleavage of amyloid precursor protein in human IMR32 cells after 2 hrs using MBPC-125 substrate by ELISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed