BDBM50484356 Skimmiarepin C

SMILES [H][C@]1([#8]C1([#6])[#6])[C@@]1([H])[#6][C@]([H])([#6](-[#8])-[#8]1)[C@@]1([H])[#6]-[#6][C@]23[#6][C@]12[#6]-[#6][C@]1([H])[C@@]2([#6])[#6]-[#6]-[#6@@H](-[#8]-[#6](=O)\[#6]=[#6](\[#6])-[#6])C([#6])([#6])[C@]2([H])[#6]-[#6@@H](-[#8])[C@@]31[#6]

InChI Key InChIKey=ITVZPGUBVVWDLH-DKQGTCRASA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50484356   

TargetEndothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
University Of Mississippi

Curated by ChEMBL
LigandPNGBDBM50484356(Skimmiarepin C)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of 1, 10-phenanthroline-induced HIF1 activation in human T47D cells after 16 hrs by HRE3-TK-luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEndothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
University Of Mississippi

Curated by ChEMBL
LigandPNGBDBM50484356(Skimmiarepin C)
Affinity DataIC50:  68nMAssay Description:Inhibition of hypoxia-induced HIF1 activation in human T47D cells after 16 hrs by HRE3-TK-luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed