BDBM50499490 CHEMBL3741992

SMILES Cc1cc(Cl)c(OCCO)cc1NC(=O)C1=CNC(=O)C[C@H]1c1ccc(F)cc1

InChI Key InChIKey=GGNOURYPUNZEOQ-HNNXBMFYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50499490   

TargetP2X purinoceptor 7(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499490(CHEMBL3741992)
Affinity DataIC50:  23nMAssay Description:Antagonist activity at human P2X7R expressed in BzATP-stimulated human 1321N1 cells incubated for 20 mins followed by BzATP stimulation measured ever...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 3(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499490(CHEMBL3741992)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of P2X3R (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 2/3(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499490(CHEMBL3741992)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of P2X2/3R (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 5(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499490(CHEMBL3741992)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of P2X5R (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 2(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499490(CHEMBL3741992)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of P2X2R (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499490(CHEMBL3741992)
Affinity DataIC50:  60nMAssay Description:Antagonist activity at P2X7R in human whole blood assessed as inhibition of LPS-induced IL-1beta production incubated for 30 mins followed by ATP add...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 4(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499490(CHEMBL3741992)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of P2X4R (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 1(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499490(CHEMBL3741992)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of P2X1R (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499490(CHEMBL3741992)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at rat P2X7R expressed in BzATP-stimulated HEK293 cells incubated for 20 mins followed by BzATP stimulation measured every 1 sec ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed