BDBM50500197 CHEMBL3746823

SMILES O=S(=O)(NC(c1cc2ccccc2o1)c1ccccc1)c1ccc2OCCCOc2c1

InChI Key InChIKey=KMUUQMAWJDDNPP-UHFFFAOYSA-N

Data  1 IC50  2 Kd  2 EC50

PDB links: 1 PDB ID matches this monomer.

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50500197   

TargetGlucokinase regulatory protein(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50500197(CHEMBL3746823)
Affinity DataKd:  1.10E+3nMAssay Description:Binding affinity to human GKRP by surface plasmon resonance analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHexokinase-4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50500197(CHEMBL3746823)
Affinity DataEC50: >1.00E+5nMAssay Description:Effect on human glucokinase activity after 60 mins by luciferase-based luminescence assay in absence of human GKRPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetGlucokinase regulatory protein(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50500197(CHEMBL3746823)
Affinity DataIC50:  1.20E+3nMAssay Description:Binding affinity to human biotinylated AviTag GKRP assessed as inhibition of protein interaction with fluorescein tagged human glucokinase by AlphaSc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetGlucokinase regulatory protein(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50500197(CHEMBL3746823)
Affinity DataEC50:  260nMAssay Description:Binding affinity to human GKRP assessed as inhibition of protein interaction with human glucokinase by measuring ATP depletion after 60 mins by lucif...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHexokinase-4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50500197(CHEMBL3746823)
Affinity DataKd: >2.00E+4nMAssay Description:Binding affinity to human glucokinase by surface plasmon resonance analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed