BDBM50501885 CHEMBL4441173::US10807974, Example 68::US10995088, Example 68::US11608330, Example 68

SMILES CS(=O)(=O)c1cc(cc(c1)S(=O)(=O)c1ccc(CN)s1)-c1ccccc1

InChI Key InChIKey=ADIBEGOVRYXDOX-UHFFFAOYSA-N

Data  26 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 26 hits for monomerid = 50501885   

TargetMembrane primary amine oxidase(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50501885(CHEMBL4441173 | US10807974, Example 68 | US1099508...)
Affinity DataIC50:  4.80E+4nMAssay Description:Inhibition of recombinant human SSAO expressed in CHO cells by MAO-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
The Institute of Cancer Research: Royal Cancer Hospital

US Patent
LigandPNGBDBM50501885(CHEMBL4441173 | US10807974, Example 68 | US1099508...)
Affinity DataIC50: >1.00E+5nMAssay Description:Promega ROS-Glo H2O2 Assay Kit, 50 ml. Cat No. G8821Inhibitors (Test compounds):10 mM stock diluted to 10, 3, 1, 0.3, 0.1, 0.03, 0.01, 0.003, 0.001, ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysyl oxidase homolog 2(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50501885(CHEMBL4441173 | US10807974, Example 68 | US1099508...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of human C-terminal His10-tagged LOXL2 (Met1 to Gln774 residues) expressed in mouse NS0 cells using cadaverine hydrochloride as substrate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50501885(CHEMBL4441173 | US10807974, Example 68 | US1099508...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of human ERG expressed in CHOK1 cells by Q-patch electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50501885(CHEMBL4441173 | US10807974, Example 68 | US1099508...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of MAOA (unknown origin) using MAO substrate measured after 1 hr by luciferin reagent-based MAO-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysyl oxidase homolog 2(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50501885(CHEMBL4441173 | US10807974, Example 68 | US1099508...)
Affinity DataIC50:  176nMAssay Description:Inhibition of human C-terminal His10-tagged LOXL2 (Met1 to Gln774 residues) expressed in mouse NS0 cells using cadaverine hydrochloride as substrate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysyl oxidase homolog 2(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50501885(CHEMBL4441173 | US10807974, Example 68 | US1099508...)
Affinity DataIC50:  439nMAssay Description:Inhibition of human C-terminal His10-tagged LOXL2 (Met1 to Gln774 residues) expressed in mouse NS0 cells using cadaverine hydrochloride as substrate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysyl oxidase homolog 3(Homo sapiens (Human))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50501885(CHEMBL4441173 | US10807974, Example 68 | US1099508...)
Affinity DataIC50:  1.35E+4nMAssay Description:Inhibition of recombinant C-terminal His-tagged human LOXL3 (1 to 753 residues) expressed in CHO cells using cadaverine hydrochloride as substrate pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysyl oxidase homolog 2(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50501885(CHEMBL4441173 | US10807974, Example 68 | US1099508...)
Affinity DataIC50:  126nMAssay Description:Inhibition of human C-terminal His10-tagged LOXL2 (Met1 to Gln774 residues) expressed in mouse NS0 cells using cadaverine hydrochloride as substrate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-lysine 6-oxidase(Sus scrofa)
The Institute of Cancer Research: Royal Cancer Hospital

US Patent
LigandPNGBDBM50501885(CHEMBL4441173 | US10807974, Example 68 | US1099508...)
Affinity DataIC50:  890nMAssay Description:LOX enzyme was obtained from pig skin by the method of Shackleton et al 1990.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProtein-lysine 6-oxidase(Mus musculus)
The Institute of Cancer Research: Royal Cancer Hospital

US Patent
LigandPNGBDBM50501885(CHEMBL4441173 | US10807974, Example 68 | US1099508...)
Affinity DataIC50:  2.50E+3nMAssay Description:To produce MDCK cysts, cells were cultured on Matrigel (Corning) with 2% Matrigel supplemented in DMEM with 10% FBS. Cysts were allowed to form for 1...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysyl oxidase homolog 2(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50501885(CHEMBL4441173 | US10807974, Example 68 | US1099508...)
Affinity DataIC50:  3.80E+3nMAssay Description:LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 20 min at room temp on a plate shaker.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysyl oxidase homolog 2(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50501885(CHEMBL4441173 | US10807974, Example 68 | US1099508...)
Affinity DataIC50:  260nMAssay Description:LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 20 hours at room temp on a plate shaker.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50501885(CHEMBL4441173 | US10807974, Example 68 | US1099508...)
Affinity DataIC50: >1.00E+5nMAssay Description:MAO-Glo Assay Kit: Promega, Cat No. V1402, MAO-A Enzyme: Promega, Cat No. V1452.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
The Institute of Cancer Research: Royal Cancer Hospital

US Patent
LigandPNGBDBM50501885(CHEMBL4441173 | US10807974, Example 68 | US1099508...)
Affinity DataIC50: >1.00E+5nMAssay Description:MAO-Glo Assay Kit: Promega, Cat No. V1402, MAO-B Enzyme: Sigma, Cat No. M7441.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProtein-lysine 6-oxidase(Homo sapiens (Human))
The Institute of Cancer Research: Royal Cancer Hospital

US Patent
LigandPNGBDBM50501885(CHEMBL4441173 | US10807974, Example 68 | US1099508...)
Affinity DataIC50:  890nMAssay Description:The following reagents were prepared:Reagents500 mM CHES, pH 9 (with NaOH), filtered (MW=207.29)20.7 g in 200 ml in dH2O10% Pluronic F-127 (store at ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProtein-lysine 6-oxidase(Homo sapiens (Human))
The Institute of Cancer Research: Royal Cancer Hospital

US Patent
LigandPNGBDBM50501885(CHEMBL4441173 | US10807974, Example 68 | US1099508...)
Affinity DataIC50:  2.50E+3nMAssay Description:Cell Culture and TransfectionAll cell lines used in this study was purchased from American Type Culture Collection (ATCC). Mycoplasma contamination w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysyl oxidase homolog 2(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50501885(CHEMBL4441173 | US10807974, Example 68 | US1099508...)
Affinity DataIC50:  3.80E+3nMAssay Description:The following reagents were prepared:Reagents500 mM CHES, pH 9 (with NaOH), filtered (MW=207.29)20.7 g in 200 ml in dH2O10% Pluronic F-127 (store at ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysyl oxidase homolog 2(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50501885(CHEMBL4441173 | US10807974, Example 68 | US1099508...)
Affinity DataIC50:  260nMAssay Description:10. Incubate for 20 hrs at room temp on a plate shaker, protected from light.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50501885(CHEMBL4441173 | US10807974, Example 68 | US1099508...)
Affinity DataIC50: >1.00E+5nMAssay Description:The following reagents were prepared:ReagentsMAO-Glo Assay Kit: Promega, Cat No. V1402MAO-A Enzyme: Promega, Cat No. V1452Clorgyline: Sigma, Cat No. ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
The Institute of Cancer Research: Royal Cancer Hospital

US Patent
LigandPNGBDBM50501885(CHEMBL4441173 | US10807974, Example 68 | US1099508...)
Affinity DataIC50: >1.00E+5nMAssay Description:The following reagents were prepared:ReagentsMAO-Glo Assay Kit: Promega, Cat No. V1402MAO-B Enzyme: Sigma, Cat No. M7441Deprenyl: Sigma, Cat No. M003...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Sus scrofa)
The Institute of Cancer Research: Royal Cancer Hospital

US Patent
LigandPNGBDBM50501885(CHEMBL4441173 | US10807974, Example 68 | US1099508...)
Affinity DataIC50:  890nMAssay Description:LOX enzyme was obtained from pig skin by the method of Shackleton et al 1990.Assay Plates:Black, flat bottom 96 well platesProcedure:1. Dilute LOX en...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysyl oxidase homolog 2(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50501885(CHEMBL4441173 | US10807974, Example 68 | US1099508...)
Affinity DataIC50:  3.80E+3nMAssay Description:LOX enzyme was obtained from pig skin by the method of Shackleton et al 1990.Assay Plates:Black, flat bottom 96 well platesProcedure:1. Dilute LOX en...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysyl oxidase homolog 2(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50501885(CHEMBL4441173 | US10807974, Example 68 | US1099508...)
Affinity DataIC50:  260nMMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50501885(CHEMBL4441173 | US10807974, Example 68 | US1099508...)
Affinity DataIC50: >1.00E+5nMAssay Description:MAO-B Enzyme: Sigma, Cat No. M7441Deprenyl: Sigma, Cat No. M003Assay Plates: 96 well white polystyrene, flat bottom plates, no lid: Fisher, Cat No. D...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
The Institute of Cancer Research: Royal Cancer Hospital

US Patent
LigandPNGBDBM50501885(CHEMBL4441173 | US10807974, Example 68 | US1099508...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant human MAOB expressed in baculovirus infected BTI insect cells using MAO substrate measured after 1 hr by luciferin reagent-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed