BDBM50502729 CHEMBL4593124::US11479539, Compound 23

SMILES COC1(CC(C)(C)C(=O)C(=C1)C#N)c1ncccc1-c1cnn(C)c1

InChI Key InChIKey=UVIJCHDXLGLQQL-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50502729   

Targethek293 luciferase(Human immunodeficiency virus type 1 group M subtyp...)
Medimmune

US Patent
LigandPNGBDBM50502729(CHEMBL4593124 | US11479539, Compound 23)
Affinity DataEC50:  56nMAssay Description:Purpose of the AssayThe purpose of this assay is to identify small molecule inhibitors of Keap1, preventing Keap1 binding to Nrf2, and thus activatin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKelch-like ECH-associated protein 1(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50502729(CHEMBL4593124 | US11479539, Compound 23)
Affinity DataEC50:  56nMAssay Description:Inhibition of KEAP1 interaction with Nrf2 in human HEK293 cells transfected with ARE-LUC assessed as activation of Nrf2 signaling pathway measured af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed