BDBM50502732 CHEMBL4557371::US11479539, Compound 69
SMILES COC1(CC(C)(C)C(=O)C(=C1)C#N)c1ncc(F)cc1-c1cnn(C)c1
InChI Key InChIKey=UFTRYWQICMMERY-UHFFFAOYSA-N
Data 3 EC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 50502732
TargetKelch-like ECH-associated protein 1(Homo sapiens (Human))
Temple University School Of Pharmacy
Curated by ChEMBL
Temple University School Of Pharmacy
Curated by ChEMBL
Affinity DataEC50: 2nMAssay Description:Inhibition of KEAP1 interaction with Nrf2 in human HEK293 cells transfected with ARE-LUC assessed as activation of Nrf2 signaling pathway measured af...More data for this Ligand-Target Pair
Affinity DataEC50: 2nMAssay Description:Purpose of the AssayThe purpose of this assay is to identify small molecule inhibitors of Keap1, preventing Keap1 binding to Nrf2, and thus activatin...More data for this Ligand-Target Pair
Affinity DataEC50: 14nMAssay Description:Purpose of the AssayThe purpose of this assay is to identify small molecule inhibitors of Keap1, preventing Keap1 binding to Nrf2, and thus activatin...More data for this Ligand-Target Pair