BDBM50504170 CHEMBL4553144

SMILES COc1ccc(cc1Cl)-c1nn(cc1-c1ccncc1)-c1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1

InChI Key InChIKey=VFOKXQSPITZZJM-UHFFFAOYSA-N

Data  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50504170   

TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
University Of Sharjah

Curated by ChEMBL
LigandPNGBDBM50504170(CHEMBL4553144)
Affinity DataIC50:  158nMAssay Description:Inhibition of human BRAF V600E mutant using MEK1 as substrate by [gamma-34P]-ATP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
University Of Sharjah

Curated by ChEMBL
LigandPNGBDBM50504170(CHEMBL4553144)
Affinity DataIC50:  22nMAssay Description:Inhibition of human p38alpha using MBP as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
University Of Sharjah

Curated by ChEMBL
LigandPNGBDBM50504170(CHEMBL4553144)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human c-MET using KKKSPGEYVNIEFG as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University Of Sharjah

Curated by ChEMBL
LigandPNGBDBM50504170(CHEMBL4553144)
Affinity DataIC50:  1.31E+4nMAssay Description:Inhibition of human ERG incubated for 4 hrs by competitive fluorescence tracer binding based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
University Of Sharjah

Curated by ChEMBL
LigandPNGBDBM50504170(CHEMBL4553144)
Affinity DataEC50:  520nMAssay Description:Inhibition of recombinant Nanoluc-tagged p38alpha (unknown origin) expressed in HEK293 cells incubated for 2 to 3 mins by NanoBRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
University Of Sharjah

Curated by ChEMBL
LigandPNGBDBM50504170(CHEMBL4553144)
Affinity DataIC50:  336nMAssay Description:Inhibition of human RAF1 using MEK1 as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed