BDBM50509567 CHEMBL4455382::US11213520, Example I-003

SMILES CN(C)C(=O)Cn1cc(cn1)-c1ccc(cc1)-c1cncc2ccccc12

InChI Key InChIKey=WULUGQONDYDNKY-UHFFFAOYSA-N

Data  3 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50509567   

TargetCyclin-C(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50509567(CHEMBL4455382 | US11213520, Example I-003)
Affinity DataIC50:  1nMAssay Description:Inhibition of CDK8/CyclinC (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM50509567(CHEMBL4455382 | US11213520, Example I-003)
Affinity DataIC50:  1.40nMAssay Description:Displacement of tracer 236 from recombinant human CDK8 incubated for 60 mins by TR-FRET based Lanthascreen assayMore data for this Ligand-Target Pair
TargetCyclin-C/Cyclin-dependent kinase 8(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM50509567(CHEMBL4455382 | US11213520, Example I-003)
Affinity DataIC50:  1.10nMAssay Description:Assay-ready plates (ARPs; Proxiplate-384 PLUS, white, PerkinElmer) with compound solution in 100% DMSO are generated on an Access Labcyte Workstation...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM50509567(CHEMBL4455382 | US11213520, Example I-003)
Affinity DataKd:  0.770nMAssay Description:Binding affinity to CDK8 (unknown origin)More data for this Ligand-Target Pair