BDBM50510905 CHEMBL4532268

SMILES [H][C@]12CCCN1CCN(CCCc1cc(Cl)c(c(Cl)c1)S(=O)(=O)N(C)c1c(C)nn(C)c1C)C2

InChI Key InChIKey=IMQPHOQRHBIWQQ-LJQANCHMSA-N

Data  7 KI

PDB links: 2 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50510905   

TargetGlycylpeptide N-tetradecanoyltransferase(Leishmania major)
Johannes Gutenberg-Universit£T Mainz

Curated by ChEMBL
LigandPNGBDBM50510905(CHEMBL4532268)
Affinity DataKi:  1.30nMAssay Description:Inhibition of Leishmania major NMT H398N mutant expressed in Escherichia coli Rosetta-2 cells using GSNKSKPK as substrate in presence of MyrCoA after...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetGlycylpeptide N-tetradecanoyltransferase(Leishmania major)
Johannes Gutenberg-Universit£T Mainz

Curated by ChEMBL
LigandPNGBDBM50510905(CHEMBL4532268)
Affinity DataKi:  2nMAssay Description:Inhibition of N-terminal TEV cleavage site-fused His6 tagged Leishmania major NMT (11 to 421 residues) expressed in Escherichia coli Rosetta-2 cells ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetGlycylpeptide N-tetradecanoyltransferase 1(Homo sapiens (Human))
Johannes Gutenberg-Universit£T Mainz

Curated by ChEMBL
LigandPNGBDBM50510905(CHEMBL4532268)
Affinity DataKi:  18nMAssay Description:Inhibition of human NMT1 L495M mutant expressed in Escherichia coli Rosetta-2 cells using GSNKSKPK as substrate in presence of MyrCoA after 30 mins b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetGlycylpeptide N-tetradecanoyltransferase 1(Homo sapiens (Human))
Johannes Gutenberg-Universit£T Mainz

Curated by ChEMBL
LigandPNGBDBM50510905(CHEMBL4532268)
Affinity DataKi:  18nMAssay Description:Inhibition of human NMT1 N473H/L495M/Q496L mutant expressed in Escherichia coli Rosetta-2 cells using GSNKSKPK as substrate in presence of MyrCoA aft...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetGlycylpeptide N-tetradecanoyltransferase(Leishmania major)
Johannes Gutenberg-Universit£T Mainz

Curated by ChEMBL
LigandPNGBDBM50510905(CHEMBL4532268)
Affinity DataKi:  37nMAssay Description:Inhibition of Leishmania major NMT L421Q mutant expressed in Escherichia coli Rosetta-2 cells using GSNKSKPK as substrate in presence of MyrCoA after...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetGlycylpeptide N-tetradecanoyltransferase 1(Homo sapiens (Human))
Johannes Gutenberg-Universit£T Mainz

Curated by ChEMBL
LigandPNGBDBM50510905(CHEMBL4532268)
Affinity DataKi:  280nMAssay Description:Inhibition of human NMT1 Q496L mutant expressed in Escherichia coli Rosetta-2 cells using GSNKSKPK as substrate in presence of MyrCoA after 30 mins b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetGlycylpeptide N-tetradecanoyltransferase 1(Homo sapiens (Human))
Johannes Gutenberg-Universit£T Mainz

Curated by ChEMBL
LigandPNGBDBM50510905(CHEMBL4532268)
Affinity DataKi:  430nMAssay Description:Inhibition of N-terminal TEV cleavage site-fused His6 tagged human NMT1 (115 to 496 residues) expressed in Escherichia coli Rosetta-2 cells using GSN...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB