BDBM50510955 CHEMBL4547264

SMILES CN1Cc2cc(cnc2C1=O)-c1ccc(s1)-c1cncc(NS(=O)(=O)c2ccc(F)cc2F)c1

InChI Key InChIKey=FPTRZWCNYNFTIS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50510955   

TargetPerforin-1(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50510955(CHEMBL4547264)
Affinity DataIC50:  7.50E+3nMAssay Description:Inhibition of perforin in human KHYG-1 cells pre-treated with compound for 20 mins assessed as reduction in KHYG-1 cells-mediated cell lysis of human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPerforin-1(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50510955(CHEMBL4547264)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibition of perforin (unknown origin) assessed as reduction in perforin-mediated cell lysis in human Jurkat T cells incubated for 30 mins by 51Cr r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed