BDBM50511138 CHEMBL4576854
SMILES CC(C)(C)c1ccc(CN2CCN(CC2)S(=O)(=O)Nc2ccc(SCCc3ccccc3)cc2C(O)=O)cc1
InChI Key InChIKey=WIWNZUYJVZDDEH-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 9 hits for monomerid = 50511138
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Yancheng Teachers University
Curated by ChEMBL
Yancheng Teachers University
Curated by ChEMBL
Affinity DataKi: 94nMAssay Description:Displacement of fluorescent-labeled BID-BH3 peptide from His-tagged human MCL-1 expressed in Escherichia coli BL21 (DE3) assessed as inhibition const...More data for this Ligand-Target Pair
3D Structure (crystal)TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Yancheng Teachers University
Curated by ChEMBL
Yancheng Teachers University
Curated by ChEMBL
Affinity DataKi: 94nMAssay Description:Inhibition of N-terminal His6-tagged human Mcl1 expressed in Escherichia coli Rosetta2 DE3 by fluorescent labeled Flu-Bid peptide based fluorescence ...More data for this Ligand-Target Pair
TargetBcl-2-related protein A1(Homo sapiens (Human))
National Institute Of Chemistry
Curated by ChEMBL
National Institute Of Chemistry
Curated by ChEMBL
Affinity DataKi: 100nMAssay Description:Inhibition of N-terminal His6-tagged human Bfl-1 (1 to 151 residues), expressed in Escherichia coli Rosetta2 DE3 by fluorescent labeled FAM-Bid pepti...More data for this Ligand-Target Pair
TargetBcl-2-related protein A1(Homo sapiens (Human))
National Institute Of Chemistry
Curated by ChEMBL
National Institute Of Chemistry
Curated by ChEMBL
Affinity DataKi: 100nMAssay Description:Displacement of fluorescent-labeled BID-BH3 peptide from His-tagged human BFL-1 (1 to 151 residues) expressed in Escherichia coli BL21 (DE3) assessed...More data for this Ligand-Target Pair
TargetBcl-2-related protein A1(Homo sapiens (Human))
National Institute Of Chemistry
Curated by ChEMBL
National Institute Of Chemistry
Curated by ChEMBL
Affinity DataKi: 680nMAssay Description:Displacement of fluorescein tagged BID BH3 peptide from His-tagged recombinant BFL-1 (1 to 151 residues) (unknown origin) expressed in Escherichia co...More data for this Ligand-Target Pair
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
National Institute Of Chemistry
Curated by ChEMBL
National Institute Of Chemistry
Curated by ChEMBL
Affinity DataKi: >2.50E+4nMAssay Description:Inhibition of N-terminal His6-tagged human Bcl-2 isoform 2 (1 to 34 residues and 92 to 202 residues with Bcl-xL sequence (35 to 50 residues) expresse...More data for this Ligand-Target Pair
Affinity DataKi: >2.50E+4nMAssay Description:Inhibition of N-terminal His6-tagged human Bcl-xL (with internal deletion of 45 to 85 amino acids and C-terminal truncation for 212 to 233 residues) ...More data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Yancheng Teachers University
Curated by ChEMBL
Yancheng Teachers University
Curated by ChEMBL
Affinity DataKd: 670nMAssay Description:Binding affinity to immobilized biotin-labeled and N-terminal His6-tagged human Mcl-1 expressed in Escherichia coli Rosetta2 DE3 by biolayer interfer...More data for this Ligand-Target Pair
TargetBcl-2-related protein A1(Homo sapiens (Human))
National Institute Of Chemistry
Curated by ChEMBL
National Institute Of Chemistry
Curated by ChEMBL
Affinity DataKd: 1.27E+3nMAssay Description:Binding affinity to immobilized biotin-labeled and N-terminal His6-tagged human Bfl-1 (1 to 151 residues), expressed in Escherichia coli Rosetta2 DE3...More data for this Ligand-Target Pair