BDBM50511548 CHEMBL4449082
SMILES C[C@H]1CN(C[C@@H](C)O1)c1cc2N(C)C(=O)C3(CCN(CC3)c3nc4N(C)CCCc4c(=O)[nH]3)c2c(F)c1
InChI Key InChIKey=KZUPFZKALLNBBV-CALCHBBNSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 18 hits for monomerid = 50511548
TargetCytochrome P450 1A2(Homo sapiens (Human))
Japanese Foundation for Cancer Research
Curated by ChEMBL
Japanese Foundation for Cancer Research
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate preincubated for 5 mins followed by NADPH addition and measured for 10 t...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
University of South Australia
Curated by ChEMBL
University of South Australia
Curated by ChEMBL
Affinity DataIC50: 1.24E+3nMAssay Description:Inhibition of PAPR2 (unknown origin)More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Japanese Foundation for Cancer Research
Curated by ChEMBL
Japanese Foundation for Cancer Research
Curated by ChEMBL
Affinity DataIC50: 36nMAssay Description:Inhibition of recombinant human N-terminal TEV cleavage site-fused/FLAG-poly his-tagged TNKS SAM-PARP domain (1024 to 1327 residues) expressed in Esc...More data for this Ligand-Target Pair
3D Structure (crystal)TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Japanese Foundation for Cancer Research
Curated by ChEMBL
Japanese Foundation for Cancer Research
Curated by ChEMBL
Affinity DataIC50: 39nMAssay Description:Inhibition of recombinant human N-terminal TEV cleavage site-fused/FLAG-poly his-tagged TNKS2 ARC5-SAM-PARP domain (613 to 1166 residues) expressed i...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
Japanese Foundation for Cancer Research
Curated by ChEMBL
Japanese Foundation for Cancer Research
Curated by ChEMBL
Affinity DataIC50: 3.10nMAssay Description:Inhibition of TNKS/TNKS2 (unknown origin) expressed in human DLD1 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferas...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
University of South Australia
Curated by ChEMBL
University of South Australia
Curated by ChEMBL
Affinity DataIC50: 1.24E+3nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged PARP2 (2 to 583 residues) expressed in baculovirus infected Sf9 cells assessed as reduction in ...More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP10(Homo sapiens (Human))
Japanese Foundation for Cancer Research
Curated by ChEMBL
Japanese Foundation for Cancer Research
Curated by ChEMBL
Affinity DataIC50: 8.05E+3nMAssay Description:Inhibition of human recombinant N-terminal TEV-cleavgae site-fused-FLAG/Polyhis-tagged PARP10 (2 to 583 residues) expressed in Escherichia coli asses...More data for this Ligand-Target Pair
TargetCytochrome P450 2C8(Homo sapiens (Human))
Japanese Foundation for Cancer Research
Curated by ChEMBL
Japanese Foundation for Cancer Research
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate preincubated for 5 mins followed by NADPH addition and measured for 10 ...More data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
Japanese Foundation for Cancer Research
Curated by ChEMBL
Japanese Foundation for Cancer Research
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using bufuralol as substrate preincubated for 5 mins followed by NADPH addition and measured for 10 to...More data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Japanese Foundation for Cancer Research
Curated by ChEMBL
Japanese Foundation for Cancer Research
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 5 mins followed by NADPH addition and measured for 10 to...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
Japanese Foundation for Cancer Research
Curated by ChEMBL
Japanese Foundation for Cancer Research
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...More data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
Japanese Foundation for Cancer Research
Curated by ChEMBL
Japanese Foundation for Cancer Research
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 5 mins followed by NADPH addition and measured for 10 t...More data for this Ligand-Target Pair
TargetCytochrome P450 2B6(Homo sapiens (Human))
Japanese Foundation for Cancer Research
Curated by ChEMBL
Japanese Foundation for Cancer Research
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 5 mins followed by NADPH addition and measured for 10 to...More data for this Ligand-Target Pair
TargetCytochrome P450 2C19(Homo sapiens (Human))
Japanese Foundation for Cancer Research
Curated by ChEMBL
Japanese Foundation for Cancer Research
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using (S)-mephenytoin as substrate preincubated for 5 mins followed by NADPH addition and measured fo...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Japanese Foundation for Cancer Research
Curated by ChEMBL
Japanese Foundation for Cancer Research
Curated by ChEMBL
Affinity DataIC50: 36nMAssay Description:Inhibition of TNKS1 (unknown origin)More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Japanese Foundation for Cancer Research
Curated by ChEMBL
Japanese Foundation for Cancer Research
Curated by ChEMBL
Affinity DataIC50: 39nMAssay Description:Inhibition of TNKS2 (unknown origin)More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
University of South Australia
Curated by ChEMBL
University of South Australia
Curated by ChEMBL
Affinity DataIC50: 1.82E+4nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
University of South Australia
Curated by ChEMBL
University of South Australia
Curated by ChEMBL
Affinity DataIC50: 1.82E+4nMAssay Description:Inhibition of recombinant human PARP1 expressed in Escherichia coli assessed as reduction in auto-PARylation using histone as substrate measured afte...More data for this Ligand-Target Pair