BDBM50511906 CHEMBL4435830::US11045448, Cpd. No. 57

SMILES [H][C@@]1(CCC[C@@H]1NC(=O)OC)[C@@](C#N)(C1CCN(CC2CN(C2)c2ccc(cc2)S(=O)(=O)C2CN(C2)C(=O)\C=C\CN(C)C)CC1)c1cccc(F)c1

InChI Key InChIKey=PJMFCNODKBGQNV-HDDNKGPMSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50511906   

TargetMenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50511906(CHEMBL4435830 | US11045448, Cpd. No. 57)
Affinity DataIC50:  3nMAssay Description:Inhibition of fluorescent probe binding to Menin (2 to 610 residues containing deletion from 460-519) (unknown origin) after 60 mins by fluorescence ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50511906(CHEMBL4435830 | US11045448, Cpd. No. 57)
Affinity DataIC50:  3.30nMAssay Description:Binding affinity to human MeninMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50511906(CHEMBL4435830 | US11045448, Cpd. No. 57)
Affinity DataIC50:  3nMAssay Description:A fluorescence polarization (FP) competitive binding assay was used to determine the binding affinities of representative menin inhibitors. A FAM lab...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50511906(CHEMBL4435830 | US11045448, Cpd. No. 57)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of menin (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed