BDBM50518036 CHEMBL4467777::US11484525, Compound BD-122LS-PZM21
SMILES C[C@@H](Cc1ccsc1)NC(=O)NC[C@H](Cc1ccc(O)cc1)N(C)C
InChI Key InChIKey=MEDBIJOVZJEMBI-YOEHRIQHSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 14 hits for monomerid = 50518036
Affinity DataKi: 1.10nMAssay Description:Inhibition of mu opioid receptor (unknown origin) assessed as reduction in intracellular cAMP accumulationMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 1.10nMAssay Description:Displacement of [3H]-Diprenorphine from mu opioid receptor (unknown origin) expressed in sf9 insect cell membranes after 1 hr by liquid scintillation...More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataKi: 18nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
TargetMu-type opioid receptor [N127C](Homo sapiens (Human))
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataKi: 37nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataKi: 46nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Homo sapiens (Human))
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataKi: 1.00E+3nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
Affinity DataEC50: 22nMAssay Description:Agonist activity at mu opioid receptor (unknown origin) assessed as beta arrestin-2 recruitment incubated for 3 days by PathHunter assayMore data for this Ligand-Target Pair
Affinity DataEC50: 10nMAssay Description:Agonist activity at mu opioid receptor (unknown origin) assessed as increase in cAMP level incubated for 40 mins by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataEC50: 57nMAssay Description:Agonist activity at human MOR expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by PathHunter assayMore data for this Ligand-Target Pair
Affinity DataEC50: 4.60nMAssay Description:Inhibition of mu opioid receptor (unknown origin) assessed as reduction in intracellular cAMP accumulationMore data for this Ligand-Target Pair
Affinity DataEC50: 52nMAssay Description:Inhibition of mu opioid receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumul...More data for this Ligand-Target Pair
Affinity DataEC50: 52nMAssay Description:Inhibition of mu opioid receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of forskolin-stimulated beta arrestin 2 recruitmen...More data for this Ligand-Target Pair
Affinity DataEC50: 4.60nMAssay Description:Agonist activity at Gi/o coupled human mu opioid receptor expressed in HEK293T cells co-expressing luciferase based cAMP biosensor and GRK2 assessed ...More data for this Ligand-Target Pair
Affinity DataEC50: 2.5nMAssay Description:Agonist activity at human MOR expressed in HEK293T cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 5 mins wit...More data for this Ligand-Target Pair