BDBM50518533 CHEMBL4521506

SMILES Fc1ccc(Nc2ncnc3cc(OCc4cn(CCCN5CCOCC5)nn4)c(NC(=O)C=C)cc23)cc1Cl

InChI Key InChIKey=DFDUYVRHGNUQHL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50518533   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Chung-Ang University

Curated by ChEMBL
LigandPNGBDBM50518533(CHEMBL4521506)
Affinity DataIC50:  12nMAssay Description:Inhibition of human N-terminal GST-tagged EGFR kinase domain (696 to end residues) expressed in baculovirus infected sf21 cells using poly(Glu, Tyr) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Chung-Ang University

Curated by ChEMBL
LigandPNGBDBM50518533(CHEMBL4521506)
Affinity DataIC50:  4nMAssay Description:Inhibition of human N-terminal GST-tagged EGFR T790M/L858R double mutant (696 to end residues) expressed in baculovirus infected sf21 cells using pol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Chung-Ang University

Curated by ChEMBL
LigandPNGBDBM50518533(CHEMBL4521506)
Affinity DataIC50:  54nMAssay Description:Inhibition of human C-terminal His6-tagged ERBB2 (676 to end residues) expressed in baculovirus infected sf21 cells using poly(Glu, Tyr) 4:1 as subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed