BDBM50519598 CHEMBL4436406

SMILES C[C@H]1Oc2cc(Cc3c(CN(C)C(=O)c4ccc(F)cc14)nn(C)c3C#N)cnc2N

InChI Key InChIKey=UNNQUIYQJKNUQS-GFCCVEGCSA-N

Data  3 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50519598   

TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50519598(CHEMBL4436406)
Affinity DataKi: <0.0200nMAssay Description:Inhibition of ALK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50519598(CHEMBL4436406)
Affinity DataKi: <0.0700nMAssay Description:Inhibition of ROS1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50519598(CHEMBL4436406)
Affinity DataKi:  0.700nMAssay Description:Inhibition of ALK L1196M (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50519598(CHEMBL4436406)
Affinity DataIC50:  21nMAssay Description:Inhibition of ALK L1196M mutant in mouse NIH-3T3 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50519598(CHEMBL4436406)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of ALK L1196M (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50519598(CHEMBL4436406)
Affinity DataIC50:  77nMAssay Description:Inhibition of ALK G1202R (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50519598(CHEMBL4436406)
Affinity DataIC50:  1nMAssay Description:Inhibition of ALK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50519598(CHEMBL4436406)
Affinity DataIC50:  5.30nMAssay Description:Inhibition of SRC (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Mus musculus)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50519598(CHEMBL4436406)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of ALK in mouse NIH-3T3 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed