BDBM50521192 CHEMBL4547537::US11260049, Ex. 121
SMILES NC[C@]1(O)CN(C[C@@H]1S(=O)(=O)c1ccc(Cl)cn1)S(=O)(=O)c1ccc(cc1Cl)C#N
InChI Key InChIKey=WLVZWRUVPREQAW-RDJZCZTQSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50521192
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells by Qpatch assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Homo sapiens (Human))
Glaxosmithkline Intellectual Property (No. 2)
US Patent
Glaxosmithkline Intellectual Property (No. 2)
US Patent
Affinity DataIC50: 5nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Homo sapiens (Human))
Glaxosmithkline Intellectual Property (No. 2)
US Patent
Glaxosmithkline Intellectual Property (No. 2)
US Patent
Affinity DataIC50: 0.5nMAssay Description:Antagonist activity at human TRPV4 expressed in BHK/AC9 cells assessed as inhibition of GSK634775-induced calcium immobilization pre-incubated for 10...More data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Reversible inhibition of CYP3A4 (unknown origin) in presence of NADPH by vivid red substrate-based assayMore data for this Ligand-Target Pair