BDBM50521995 CHEMBL4578182

SMILES Cl.Cl.Cc1c(cnn1-c1ccc(F)cn1)C(=O)Nc1nc(C2CCC2)c(CCN2CCCCC2)s1

InChI Key InChIKey=PWDSEIQTSDGRQI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50521995   

TargetTransient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50521995(CHEMBL4578182)
Affinity DataIC50:  0.320nMAssay Description:Inhibition of rat TRPV4 expressed in HEK293 cells assessed as reduction in Ca2+ influx incubated for 30 mins by Fluo4-AM dye basedMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 4(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50521995(CHEMBL4578182)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human TRPV4 expressed in HEK293 cells assessed as reduction in Ca2+ influx incubated for 30 mins by Fluo4-AM dye basedMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed