BDBM50526270 CHEMBL4554474

SMILES COc1cc(ccc1C(N)=O)-c1cnc2ccc(NC(C)C)nn12

InChI Key InChIKey=IBZJJCFFBCEGPS-UHFFFAOYSA-N

Data  2 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50526270   

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Homo sapiens (Human))
University Of Leicester

Curated by ChEMBL
LigandPNGBDBM50526270(CHEMBL4554474)
Affinity DataIC50:  218nMAssay Description:Inhibition of dephosphorylated IRE1alpha (G547 to L977 residues) (unknown origin) autophosphorylation at S724 after 25 mins in presence of ATP by dis...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Homo sapiens (Human))
University Of Leicester

Curated by ChEMBL
LigandPNGBDBM50526270(CHEMBL4554474)
Affinity DataIC50:  1.18E+3nMAssay Description:Displacement for LanthaScreen tracer from dephosphorylated IRE1alpha (G547 to L977 residues) (unknown origin) ATP binding site KEN domain after 60 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Homo sapiens (Human))
University Of Leicester

Curated by ChEMBL
LigandPNGBDBM50526270(CHEMBL4554474)
Affinity DataEC50:  143nMAssay Description:Activation of dephosphorylated IRE1alpha (G547 to L977 residues) (unknown origin)-dependent cleavage of FAM-labeled stem-loop RNA containing the XBP1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB