BDBM50527653 CHEMBL4527606

SMILES Nc1nn(-c2ccc3cn[nH]c3c2)c2cc(cnc12)-c1ccnn1Cc1ccc(Cl)cc1Cl

InChI Key InChIKey=ZTSBSKOYWGNDHO-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50527653   

TargetCytochrome P450 2C9(Homo sapiens (Human))
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50527653(CHEMBL4527606)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of human liver microsome CYP2C9 using diclofenac as substrate incubated for 5 to 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50527653(CHEMBL4527606)
Affinity DataIC50:  1.06E+4nMAssay Description:Inhibition of human liver microsome CYP1A2 using phenacetin as substrate incubated for 5 to 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50527653(CHEMBL4527606)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of human liver microsome CYP2D6 using dextromethorphan as substrate incubated for 5 to 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50527653(CHEMBL4527606)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of human liver microsome CYP3A4 using midazolam as substrate incubated for 5 to 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5'-nucleotidase(Homo sapiens (Human))
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50527653(CHEMBL4527606)
Affinity DataIC50:  57nMAssay Description:Inhibition of recombinant human CD73 expressed in CHO cells in 2 % DMSO using AMP as substrate preincubated for 60 mins followed by substrate additio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50527653(CHEMBL4527606)
Affinity DataIC50:  2.51E+4nMAssay Description:Inhibition of human liver microsome CYP2C19 using S-mephenytoin as substrate incubated for 5 to 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed