BDBM50527981 CHEMBL4563661::US11634404, Compound 40

SMILES COc1ccc(cc1)C(=O)N1CCN(CCOc2cccnc2)CC1

InChI Key InChIKey=VOKCKVQKMXVJNW-UHFFFAOYSA-N

Data  2 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50527981   

TargetD(3) dopamine receptor(Homo sapiens (Human))
National Institute Of Neurological Disorders And Stroke

Curated by ChEMBL
LigandPNGBDBM50527981(CHEMBL4563661 | US11634404, Compound 40)
Affinity DataEC50:  17nMAssay Description:Agonist activity at human D3R expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
National Institute Of Neurological Disorders And Stroke

Curated by ChEMBL
LigandPNGBDBM50527981(CHEMBL4563661 | US11634404, Compound 40)
Affinity DataEC50:  2.90E+3nMAssay Description:Agonist activity at human D2R expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
National Institute Of Neurological Disorders And Stroke

Curated by ChEMBL
LigandPNGBDBM50527981(CHEMBL4563661 | US11634404, Compound 40)
Affinity DataIC50: >1.00E+5nMAssay Description:For a secondary-screen and selectivity assays, DAR PathHunter® βarrestin GPCR cell lines from DiscoverX (Fremont, Calif.) were used. In the D2 R...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(3) dopamine receptor(Homo sapiens)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50527981(CHEMBL4563661 | US11634404, Compound 40)
Affinity DataEC50:  17nMAssay Description:Compounds were tested for their ability to compete with the orthosteric radioligand [3H]methylspiperone for binding to the D3 DAR using stable HEK ce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
National Institute Of Neurological Disorders And Stroke

Curated by ChEMBL
LigandPNGBDBM50527981(CHEMBL4563661 | US11634404, Compound 40)
Affinity DataEC50:  2.90E+3nMAssay Description:For a secondary-screen and selectivity assays, DAR PathHunter® βarrestin GPCR cell lines from DiscoverX (Fremont, Calif.) were used. In the D2 R...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
National Institute Of Neurological Disorders And Stroke

Curated by ChEMBL
LigandPNGBDBM50527981(CHEMBL4563661 | US11634404, Compound 40)
Affinity DataIC50: >1.00E+5nMAssay Description:Antagonist activity at human D2R expressed in CHOK1 cells assessed as inhibition of dopamine-induced beta-arrestin recruitment measured after 120 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed