BDBM50529398 CHEMBL4549761::US11731973, Example 31
SMILES CC(C)n1nc(-c2ccc3oc(N)nc3c2)c2c(Cl)nc(N)nc12
InChI Key InChIKey=YDFGZXSSYDSJRM-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 50529398
Affinity DataKi: 10nMAssay Description:Inhibition of human recombinant GST-tagged mTOR catalytic domain (1360 to 2549 residues) expressed in baculovirus expression system using GFP-4E-BP1 ...More data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:The model for screening the inhibitory activity of the molecules on mTOR was developed with the LANTHASCREEN technology (Lifetechnologies). The...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Nestl�
Curated by ChEMBL
Nestl�
Curated by ChEMBL
Affinity DataKi: 920nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate measured after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of mTORC2 in human A431 cells assessed as AKT phosphorylation at S473 residue incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of mTORC1 in human A431 cells assessed as S6RP phosphorylation incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair