BDBM50529401 CHEMBL4585005

SMILES CC(C)n1nc(-c2ccc3oc(N)nc3c2)c2c1nc[nH]c2=O

InChI Key InChIKey=WXUZDBRGJSWGID-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50529401   

TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Nestl�

Curated by ChEMBL
LigandPNGBDBM50529401(CHEMBL4585005)
Affinity DataKi:  28nMAssay Description:Inhibition of human recombinant GST-tagged mTOR catalytic domain (1360 to 2549 residues) expressed in baculovirus expression system using GFP-4E-BP1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50529401(CHEMBL4585005)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate measured after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTarget of rapamycin complex subunit LST8(Homo sapiens)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50529401(CHEMBL4585005)
Affinity DataIC50:  30nMAssay Description:Inhibition of mTORC1 in human A431 cells assessed as S6RP phosphorylation incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTarget of rapamycin complex 2 subunit MAPKAP1(Homo sapiens)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50529401(CHEMBL4585005)
Affinity DataIC50:  130nMAssay Description:Inhibition of mTORC2 in human A431 cells assessed as AKT phosphorylation at S473 residue incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed