BDBM50529405 CHEMBL4588610

SMILES CC(C)n1nc(-c2ccc3oc(N)nc3c2)c2c(Br)nc(N)nc12

InChI Key InChIKey=BJEPBULKEVIYBP-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50529405   

TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Nestl�

Curated by ChEMBL
LigandPNGBDBM50529405(CHEMBL4588610)
Affinity DataKi:  21nMAssay Description:Inhibition of human recombinant GST-tagged mTOR catalytic domain (1360 to 2549 residues) expressed in baculovirus expression system using GFP-4E-BP1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50529405(CHEMBL4588610)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate measured after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTarget of rapamycin complex subunit LST8(Homo sapiens)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50529405(CHEMBL4588610)
Affinity DataIC50:  35nMAssay Description:Inhibition of mTORC1 in human A431 cells assessed as S6RP phosphorylation incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTarget of rapamycin complex 2 subunit MAPKAP1(Homo sapiens)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50529405(CHEMBL4588610)
Affinity DataIC50:  60nMAssay Description:Inhibition of mTORC2 in human A431 cells assessed as AKT phosphorylation at S473 residue incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed