BDBM50532616 CHEMBL4532382

SMILES CNc1nccc(n1)N1CC[C@@H](C1)NC(=O)Nc1ccc(CN2CCOCC2)c(c1)C(F)(F)F

InChI Key InChIKey=LVIYMOOJJGCMCP-KRWDZBQOSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50532616   

TargetCyclin-C(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50532616(CHEMBL4532382)
Affinity DataIC50:  17nMAssay Description:Displacement of tracer236 from full-length His-tagged CDK8/cyclin C (unknown origin) incubated for 1 hr by TR-FRET analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50532616(CHEMBL4532382)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CDK8 in IFN-gamma-induced human HCT116 cells assessed as suppression of STAT1 phosphorylation at serine727 residue incubated for 24 hrs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50532616(CHEMBL4532382)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CDK8 in IFN-gamma-induced human HCT116 cells assessed as suppression of STAT1 phosphorylation at serine727 residue incubated for 24 hrs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetCyclin-C(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50532616(CHEMBL4532382)
Affinity DataIC50:  17nMAssay Description:Displacement of tracer236 from full-length His-tagged CDK8/cyclin C (unknown origin) incubated for 1 hr by TR-FRET analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB