BDBM50533064 CHEMBL4538740

SMILES CN(C)C(=O)CCNc1ccc2c(C(=O)NCC3CCC(F)(F)CC3)c(Cl)ccc2n1

InChI Key InChIKey=NRDZOWINXSSAGN-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50533064   

TargetP2X purinoceptor 7(Homo sapiens (Human))
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50533064(CHEMBL4538740)
Affinity DataIC50: <10nMAssay Description:Antagonist activity at human P2X7 receptor expressed in THP1 cells assessed as inhibition of BzATP-induced IL-1beta release preincubated for 20 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50533064(CHEMBL4538740)
Affinity DataIC50: <10nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced pore formation incubated for 20 mins fol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50533064(CHEMBL4538740)
Affinity DataIC50: <10nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced pore formation incubated for 20 mins fol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50533064(CHEMBL4538740)
Affinity DataIC50: <10nMAssay Description:Antagonist activity at human P2X7 receptor expressed in THP1 cells assessed as inhibition of BzATP-induced IL-1beta release preincubated for 20 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed