BDBM50535994 CHEMBL4548927

SMILES COCc1ccc(c(F)n1)-c1ccc2ncc(C(N)=O)c(N[C@@H](C)c3ccn(C)n3)c2c1

InChI Key InChIKey=BNPUWPZHENSNKH-ZDUSSCGKSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50535994   

TargetSerine-protein kinase ATM(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50535994(CHEMBL4548927)
Affinity DataIC50:  63nMAssay Description:Inhibition of ATM phosphorylation at Ser-1981 residue in human HT-29 cells incubated for 1 hr followed by X-ray irradiation by Hoechst staining based...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50535994(CHEMBL4548927)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of human ERG by electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50535994(CHEMBL4548927)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of ATR in human HT-29 cells assessed as reduction in Chk1 phosphorylation at Ser-345 residue after 60 mins in presence of 4-nitroquinoline...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed