BDBM50536094 CHEMBL4541192

SMILES Cc1nc2cccc(-c3cc4C(=O)N[C@H](CCN)c4[nH]3)c2nc1NC(C)(C)C

InChI Key InChIKey=YKRWZGXTOYQHJI-OAHLLOKOSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50536094   

TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50536094(CHEMBL4541192)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of full length recombinant Pim-1 (unknown origin) assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 resid...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1/pim-2/pim-3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50536094(CHEMBL4541192)
Affinity DataIC50:  22nMAssay Description:Inhibition of pan Pim in human KMS-12-BM cells assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 residue after 110 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50536094(CHEMBL4541192)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of full length recombinant Pim-2 (unknown origin) assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 resid...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed