BDBM50536790 CHEMBL4575118

SMILES Cc1ccc(cc1)-c1nn(cc1C(=O)NOCc1ccccc1F)-c1ccccc1

InChI Key InChIKey=HVEABAGWWBLXHR-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50536790   

TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Anhui Agricultural University

Curated by ChEMBL
LigandPNGBDBM50536790(CHEMBL4575118)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Anhui Agricultural University

Curated by ChEMBL
LigandPNGBDBM50536790(CHEMBL4575118)
Affinity DataIC50:  610nMAssay Description:Inhibition of MEK1 in BRAF mutant human A549 cells assessed as reduction in ERK1/2 phosphorylation by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Anhui Agricultural University

Curated by ChEMBL
LigandPNGBDBM50536790(CHEMBL4575118)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Anhui Agricultural University

Curated by ChEMBL
LigandPNGBDBM50536790(CHEMBL4575118)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of HER2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Anhui Agricultural University

Curated by ChEMBL
LigandPNGBDBM50536790(CHEMBL4575118)
Affinity DataIC50:  1.56E+4nMAssay Description:Inhibition of FAK in human MCF7 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Anhui Agricultural University

Curated by ChEMBL
LigandPNGBDBM50536790(CHEMBL4575118)
Affinity DataIC50:  91nMAssay Description:Inhibition of recombinant full length human N-terminal GST-tagged C-terminal His6-tagged MEK1 expressed in Escherichia coli using myelin basic protei...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Anhui Agricultural University

Curated by ChEMBL
LigandPNGBDBM50536790(CHEMBL4575118)
Affinity DataIC50:  8.30E+3nMAssay Description:Inhibition of Aurora A (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed